What Anxiety Medication Is Best for Me?
A guide to help you understand your options
The Honest Answer
There's no single "best" anxiety medication — the right choice depends on your specific symptoms, medical history, other medications, lifestyle, and personal preferences. What works great for one person may not work for another. That's why working with a psychiatrist is so important.
Your Main Options
SSRIs (First-Line Treatment)
Zoloft, Lexapro, Prozac, Paxil, Celexa
- ✓ Most commonly prescribed for anxiety
- ✓ Effective for most anxiety disorders
- ✓ Generally well-tolerated
- ✓ Non-addictive
SNRIs
Effexor, Cymbalta, Pristiq
- ✓ Good for anxiety with depression
- ✓ May help with chronic pain
- ✓ Can be energizing
BuSpar (Buspirone)
Specifically for generalized anxiety
- ✓ Non-addictive
- ✓ No sedation
- ✓ Minimal side effects
- ✓ Can combine with antidepressants
Hydroxyzine
Non-addictive, fast-acting option
- ✓ Works within 30-60 minutes
- ✓ Can use as-needed
- ✓ No addiction risk
- ✓ Helps with sleep too
Factors That Affect the Choice
GAD, panic, social anxiety?
Depression, ADHD, pain?
What worked or didn't?
Weight, sexual, sedation?
Drug interactions matter
Work, driving, schedule?
Quick Decision Guide
If you have anxiety + depression:
SSRIs or SNRIs are often first choice — they treat both.
If you need quick relief:
Hydroxyzine works fast and is non-addictive. BuSpar takes weeks but is great long-term.
If you're worried about weight gain:
BuSpar, Lexapro, and Wellbutrin (if depression present) are weight-neutral options.
If you're concerned about sexual side effects:
BuSpar and Wellbutrin have minimal sexual side effects.
Ready to Find Your Answer?
Our psychiatrists can evaluate your specific situation and recommend the best option for you.