⚠️ Key Safety Facts
- 75% experience mild dissociation
- 1 in 50 need blood pressure intervention
- Zero addiction cases in clinical trials
- FDA-mandated 2-hour monitoring
Common Spravato Side Effects
Based on FDA clinical trial data, most patients experience mild-to-moderate effects during/after treatment:
| Side Effect |
Frequency |
Duration |
| Dizziness |
45% |
1-2 hours |
| Nausea |
33% |
30-90 mins |
| Dissociation |
61% |
40-75 mins |
Our team at Next Step Psychiatry prepares patients with pre-treatment hydration and positioning strategies to minimize discomfort.
Serious Side Effects & Risks
Immediate Risks Requiring Intervention
- Hypertension: 14% experience ≥15 mmHg BP increase
- Sedation: 8% require extended monitoring
- Bladder Issues: Rare (0.7%) but monitored
Contraindications
- ❌ Uncontrolled hypertension
- ❌ Aneurysm history
- ❌ Pregnancy (Category C)
Long-Term Side Effects
Based on 3-year safety studies:
- No cognitive decline
- No addiction potential at clinical doses
- 5% report persistent mild dissociation
Managing Side Effects
During Treatment
- Recline at 45° angle
- Use grounding techniques (music, weighted blankets)
- Sip ginger tea pre-session
Post-Treatment
- 24-hour driving ban
- Coordinate rides via our support team
- Hydration protocol
Safety Protocols at Next Step Psychiatry
- ✔️ Pre-treatment BP screening
- ✔️ Emergency medications on-site
- ✔️ 1:1 staff monitoring
- ✔️ Post-discharge check-ins
Frequently Asked Questions
Does Spravato cause permanent dissociation?
No long-term dissociation has been reported in clinical trials. Our REMS program tracks all patient outcomes.
Can I take painkillers with Spravato?
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