Paxil (Paroxetine) for Anxiety and Depression
A potent SSRI approved for multiple anxiety disorders
What Is Paxil?
Paxil (paroxetine) is a selective serotonin reuptake inhibitor (SSRI) that's FDA-approved for more anxiety disorders than any other antidepressant. It's particularly effective for social anxiety disorder and panic disorder.
Paxil is one of the most potent SSRIs at blocking serotonin reuptake, which contributes to its effectiveness but also means it requires careful management when discontinuing.
FDA-Approved Uses
Paxil has more FDA-approved indications than most antidepressants:
Treatment Timeline
Week 1-2
Adjustment period. Possible nausea, headache, drowsiness, or temporary anxiety increase.
Week 2-4
Anxiety reduction begins. Sleep and appetite may improve. Side effects decrease.
Week 4-8
Full therapeutic effects. Significant improvement in depression and anxiety symptoms.
Dosing Information
| Condition | Starting Dose | Target Dose |
|---|---|---|
| Depression | 20mg daily | 20-50mg daily |
| GAD/Social Anxiety | 20mg daily | 20-50mg daily |
| Panic Disorder | 10mg daily | 40mg daily |
| OCD | 20mg daily | 40-60mg daily |
Important: Discontinuation
Paxil has a short half-life and is known for causing discontinuation symptoms when stopped abruptly or tapered too quickly. Symptoms can include:
- • Dizziness and "brain zaps"
- • Nausea and flu-like symptoms
- • Irritability and mood swings
- • Insomnia and vivid dreams
Always taper Paxil slowly under medical supervision. Never stop abruptly.
Common Side Effects
Drowsiness
Nausea
Dry mouth
Weight gain
Sexual dysfunction
Sweating
Constipation
Dizziness
Note: Paxil tends to be more sedating and associated with more weight gain than some other SSRIs.
Pros and Cons
Pros
Cons
Questions About Paxil?
Our team can help determine the best treatment for your needs.