Effexor (Venlafaxine)
A powerful SNRI for depression, anxiety, and panic disorder
What Is Effexor?
Effexor (venlafaxine) is a serotonin-norepinephrine reuptake inhibitor (SNRI) FDA-approved for major depressive disorder, generalized anxiety disorder (GAD), social anxiety disorder, and panic disorder.
Effexor is available as both immediate-release (Effexor) and extended-release (Effexor XR) formulations, with the XR version being more commonly prescribed due to once-daily dosing and better tolerability.
FDA-Approved Uses
How Effexor Works
Effexor has a unique dose-dependent mechanism:
At Lower Doses (75-150mg)
Primarily blocks serotonin reuptake, similar to SSRIs
At Higher Doses (150-225mg+)
Also blocks norepinephrine reuptake, providing dual action for increased efficacy
At Very High Doses (300mg+)
May also affect dopamine, though this effect is minimal
Dosing Information
| Phase | Dose | Notes |
|---|---|---|
| Starting Dose | 37.5-75mg daily | Take with food |
| Therapeutic Dose | 75-225mg daily | Most effective range |
| Maximum Dose | 225-375mg daily | Higher doses for severe depression |
Treatment Timeline
Week 1-2
Adjustment period. Possible nausea, headache, sleep changes, or increased anxiety.
Week 2-4
Early improvements in energy, sleep, and anxiety. Side effects begin to diminish.
Week 4-8
Full therapeutic effects typically achieved for both depression and anxiety.
Important: Discontinuation Syndrome
Effexor has a short half-life and is known for causing discontinuation symptoms if stopped suddenly or tapered too quickly. Symptoms can include dizziness, "brain zaps," nausea, irritability, and flu-like symptoms.
Always taper Effexor gradually under medical supervision. Never stop abruptly.
Common Side Effects
Nausea
Headache
Dizziness
Insomnia
Dry mouth
Sweating
Loss of appetite
Sexual dysfunction
Monitor Blood Pressure
Effexor can increase blood pressure, especially at higher doses. Regular monitoring is recommended.
Questions About Effexor?
Our psychiatric team can help optimize your treatment.