Wellbutrin (Bupropion)
The unique antidepressant that energizes without weight gain or sexual side effects
What Makes Wellbutrin Different?
Wellbutrin (bupropion) is an atypical antidepressant that works differently from SSRIs and SNRIs. It's FDA-approved for major depressive disorder, seasonal affective disorder (SAD), and smoking cessation (as Zyban).
Unlike most antidepressants, Wellbutrin doesn't cause weight gain or sexual dysfunction — in fact, it often helps with both. It's also used off-label for ADHD and as an add-on to other antidepressants.
Why Patients Love Wellbutrin
Often promotes weight loss
May actually improve libido
Combats fatigue and lethargy
Helps with concentration and ADHD symptoms
Reduces nicotine cravings
Convenient extended-release option
How Wellbutrin Works
Wellbutrin is a norepinephrine-dopamine reuptake inhibitor (NDRI). Unlike SSRIs that target serotonin, Wellbutrin increases dopamine and norepinephrine:
Dopamine Effects
- • Improved motivation
- • Enhanced pleasure/reward
- • Better concentration
- • Reduced cravings
Norepinephrine Effects
- • Increased energy
- • Better alertness
- • Improved focus
- • Enhanced mental clarity
Available Formulations
Wellbutrin XL (Extended-Release)
150mg, 300mg, 450mg — Once daily
Most commonly prescribed. Take in the morning.
Wellbutrin SR (Sustained-Release)
100mg, 150mg, 200mg — Twice daily
Take at least 8 hours apart.
Wellbutrin IR (Immediate-Release)
75mg, 100mg — Three times daily
Rarely used due to higher seizure risk.
When Will It Work?
Week 1
Some patients notice increased energy and improved focus early. Possible insomnia or dry mouth.
Week 2-4
Mood improvements become noticeable. Energy and motivation continue to improve.
Week 4-6
Full antidepressant effects typically achieved.
Common Side Effects
Insomnia
Dry mouth
Headache
Nausea
Agitation/restlessness
Tremor
Seizure Risk Warning
Wellbutrin can lower seizure threshold. Risk increases with doses above 450mg/day, history of seizures, eating disorders, or alcohol/benzodiazepine withdrawal.
Who Should Avoid Wellbutrin?
Is Wellbutrin Right for You?
Our psychiatric team can help determine the best treatment.