How Long Does Lexapro Take to Work?
A comprehensive timeline for Lexapro (escitalopram) treatment
The Short Answer
Most patients begin experiencing benefits from Lexapro within 1-2 weeks, with full therapeutic effects typically reached by 4-6 weeks. Physical symptoms like sleep and energy often improve before mood and anxiety symptoms.
About Lexapro
Lexapro (escitalopram) is one of the most commonly prescribed antidepressants and is FDA-approved for both major depressive disorder and generalized anxiety disorder. It's known for being well-tolerated with fewer side effects than many other SSRIs.
As a "pure" SSRI, Lexapro is highly selective for serotonin transporters, which may explain its cleaner side effect profile compared to older antidepressants.
Week-by-Week Timeline
Days 1-7: Adjustment
- • Your body begins adjusting to the medication
- • Possible mild side effects (nausea, headache, sleep changes)
- • Little to no noticeable mood improvement yet
- • Some patients notice slight anxiety increase initially
Week 2: Early Changes
- • Sleep quality often begins improving
- • Energy levels may increase
- • Physical anxiety symptoms may decrease
- • Side effects typically diminishing
Week 3-4: Noticeable Improvement
- • Clearer mood improvements emerge
- • Reduced worry and anxiety
- • Better concentration and focus
- • Others may notice positive changes in you
Week 4-6: Full Effect
- • Maximum therapeutic benefits achieved
- • Sustained improvement in mood and anxiety
- • Better overall quality of life
- • This is when your provider will assess response
Signs Lexapro Is Working
Typical Dosing
Starting Dose: 10mg daily
Some start at 5mg if sensitive
Therapeutic Dose: 10-20mg daily
Most patients do well at 10mg
Maximum Dose: 20mg daily
Higher doses don't add benefit in most cases
What If Lexapro Isn't Working?
If you don't see improvement after 4-6 weeks at a therapeutic dose:
Dose Adjustment
Your provider may increase the dose to 20mg
Give It More Time
Some patients need 8 weeks for full effect
Add-On Therapy
Another medication might be added
Switch Medications
A different antidepressant may work better
Don't stop Lexapro without talking to your provider first. If you need to stop, it should be tapered gradually.
Questions About Lexapro?
Our psychiatric team can help optimize your treatment.