Hydroxyzine for Anxiety
A non-addictive option for fast-acting anxiety relief
Why Providers Like Hydroxyzine
Non-Addictive
No dependence or withdrawal risk
Fast-Acting
Works within 30-60 minutes
As-Needed Use
Can be taken only when needed
What Is Hydroxyzine?
Hydroxyzine is an antihistamine that has been used for decades to treat anxiety, allergies, and itching. Brand names include Vistaril (hydroxyzine pamoate) and Atarax (hydroxyzine HCl).
Unlike benzodiazepines (Xanax, Ativan), hydroxyzine is not a controlled substance and doesn't carry risks of addiction or dependence, making it an attractive option for anxiety treatment.
How Hydroxyzine Works
Hydroxyzine reduces anxiety through several mechanisms:
Blocks Histamine (H1)
Produces calming and sedating effects
Affects Serotonin (5-HT2A)
May contribute to anti-anxiety effects
Central Nervous System Effects
Reduces activity in parts of the brain associated with anxiety
How Quickly Does It Work?
15-30 Minutes
Begin feeling calming effects
1-2 Hours
Peak effects reached
4-6 Hours
Duration of effects
Dosing Information
For Anxiety: 25-100mg up to 4x daily
Usually 25-50mg as needed
For Sleep: 25-100mg at bedtime
Sedating effects helpful for insomnia
Maximum: 400mg/day (divided doses)
Most patients use much less
Common Side Effects
Drowsiness (most common)
Dry mouth
Headache
Dizziness
Note: The main side effect is sedation. Avoid driving or operating machinery until you know how it affects you.
Hydroxyzine vs Benzodiazepines
| Feature | Hydroxyzine | Benzodiazepines |
|---|---|---|
| Addiction Risk | None | High |
| Onset | 30-60 min | 15-30 min |
| Withdrawal | None | Can be severe |
| Controlled? | No | Yes (Schedule IV) |
Questions About Hydroxyzine?
Our psychiatric team can help determine if it's right for you.