Cymbalta (Duloxetine) for Anxiety and Depression
A versatile SNRI for mood disorders and chronic pain
What Is Cymbalta?
Cymbalta (duloxetine) is a serotonin-norepinephrine reuptake inhibitor (SNRI) that's FDA-approved for multiple conditions including major depressive disorder, generalized anxiety disorder, fibromyalgia, diabetic peripheral neuropathic pain, and chronic musculoskeletal pain.
Its unique ability to address both mood disorders and chronic pain makes it an excellent choice for patients dealing with both conditions simultaneously.
FDA-Approved Uses
How Cymbalta Works
Cymbalta increases levels of both serotonin and norepinephrine by blocking their reuptake in the brain:
Serotonin Effects
- • Mood improvement
- • Anxiety reduction
- • Sleep regulation
- • Appetite control
Norepinephrine Effects
- • Increased energy
- • Better concentration
- • Pain signal modulation
- • Motivation boost
Treatment Timeline
Week 1-2
Adjustment period. Possible nausea, dry mouth, or drowsiness. Pain relief may begin before mood improvements.
Week 2-4
Noticeable reduction in anxiety. Energy and concentration often improve. Side effects diminish.
Week 4-8
Full therapeutic effects for depression and anxiety. Maximum pain relief typically achieved.
Dosing Information
Starting Dose: 30mg daily
May start at 20mg for sensitive patients
Therapeutic Dose: 60mg daily
Effective for most conditions
Maximum Dose: 120mg daily
For depression; 60mg max for anxiety/pain
Tip: Cymbalta capsules should be swallowed whole. Taking with food may reduce stomach upset.
Common Side Effects
Nausea
Dry mouth
Fatigue
Constipation
Decreased appetite
Dizziness
Sweating
Insomnia
Important: Don't stop Cymbalta suddenly. Gradual tapering is required to avoid withdrawal symptoms (discontinuation syndrome).
Cymbalta's Unique Pain Benefits
One of Cymbalta's distinguishing features is its ability to reduce chronic pain. This makes it particularly valuable for patients with:
Is Cymbalta Right for You?
Our psychiatric team can help evaluate your treatment options.